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45 Additionally, low ALB levels reflected intestinal leakage of severe colitis, which resulted in increased intestinal loss of infliximab

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Seventeen individuals were confirmed with direct molecular testing and one (III.1 in family 1) was not alive when genetic confirmation became available but is an obligate carrier due to the segregation pattern within the family

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Hageman GS, Luthert PJ, Victor Chong NH, Johnson LV, Anderson DH, Mullins RF

Thus, it is intriguing that cell death unambiguously triggered by intracellular oxidation can be genetically reverted and that this is the case whether the initial ROS trigger is excess singlet oxygen generated in the chloroplast or H2O2formed in the peroxisomes (Wagner et al., 2004